Metabolic Abnormalities in Colorectal Cancer Patients

Abstract

Background: The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) and percent of HOMA beta-cell function (HOMA-beta%) in non-obese and obese colorectal cancer patients. 

Methods: The study comprised a total of 300 adult patients (171 men and 129 women) with various stages of colorectal adenocarcinoma. The HOMA-IR and HOMA-beta% indexes and fasting serum concentrations of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides were determined. According waist circumference values, the examined subjects were divided into two groups: group A (waist circumference < 94 cm for men and < 80 cm for women) and B (waist circumference < 94 cm for men and >= 80cm for women). 

Results: The prevalence of overweight or obesity, estimated by circumference measurements, was identified in 58.5% of the examined subjects (group B). The average fasting serum concentration of biochemical parameters and HOMA-IR index in the group B was statistically significantly higher vs those in the A group (P < 0.001). The HOMA-beta% index did not differ statistically in the analyzed groups (P < 0.05).

Conclusions: Majority of colorectal cancer patients have overweight or obesity. They are associated with hyperglycaemia, insulin resistance, hyperinsulinemia and worse lipid profile.




doi:10.4021/jem103w