Demographic and Clinical Factors Associated With the Appropriate Target Thyroid-Stimulating Hormone Values in Patients With Primary Hypothyroidism Treated With Levothyroxine

Lara Moreira Baptista de Sousa, Elisa Baranski Lamback, Thomaz Schroder Lameirinhas, Michelle Botelho Caarls, Leonardo Vieira Neto

Abstract


Background: Hypothyroidism control is inadequate in up to 30-40% of patients. This study aimed to determine the control rate of primary hypothyroidism and the demographic and clinical factors associated with the hypothyroidism control.

Methods: An observational and retrospective study was conducted between January 2014 and October 2015. Data were obtained from 174 medical records. Regarding hypothyroidism control analysis, patients were subdivided into two groups: the appropriate control group and the inappropriate control group. Autoimmune and post-surgical hypothyroidism secondary to benign nodular thyroid disease (BNTD) was classified as of benign etiology, and differentiated thyroid carcinoma (DTC) as of malignant origin.

Results: The majority of patients consisted of women (93.68%), with a mean age of 55.53 ± 14.13 years old. The most common etiology was of autoimmune origin (41.95%). Adequate control of hypothyroidism was found in 55.17% of patients. Patients who had longer disease duration (P = 0.002), who kept using the same brand of levothyroxine (P = 0.001) and who were non-smokers (P = 0.004) had better control, and hypothyroidism from benign etiology also tended to be associated with better control (P = 0.08).

Conclusions: Primary hypothyroidism still has a high percentage of poor control seen worldwide, despite its relatively simple treatment. In this study, almost 50% of the patients had inadequate control of hypothyroidism. The factors associated with good control, both of benign and malignant origin, were related to the use of the same brand of levothyroxine and to not smoking, and the benign etiology group tended to correlate with better treatment control.




J Endocrinol Metab. 2016;6(4):109-115
doi: http://dx.doi.org/10.14740/jem367w

 


Keywords


Primary hypothyroidism; Thyroid cancer; Autoimmune hypothyroidism

Full Text: HTML PDF
 
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


 

     

Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board

Archives

Copyright

Company Profile

Editorial Office

Misconduct and Retraction

Permissions

Company Registration

Contact Us

Abstracting and Indexing

ICMJE

Ownership

Instructions to Authors

Access

Declaration of Helsinki

Contact Publisher

Submission Checklist

Reprints

Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy

Disclaimer

Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians

Careers

Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal

       
       

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

DECLARATION: THIS JOURNAL SITE OUTLOOK IS DESIGNED BY THE PUBLISHER AND COPYRIGHT PROTECTED. DO NOT COPY!