Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 3, Number 1-2, April 2013, pages 1-6
Comparison Among the Daily Levothyroxine Doses According to the Etiology of Hypothyroidism
Tables
Primary Hypothyroidism | Central Hypothyroidism | Post-I131 | Post thyroidectomy (benign causes) | Post thyroidectomy (malign causes) | P value ‡ | |
---|---|---|---|---|---|---|
(‡) P value for comparison between groups. | ||||||
Women n (%) | 321 (89.9) | 9 (56.3) | 18 (90.0) | 88 (95.7) | 58 (93.5) | 0.001 |
Age (Mean, years) | 51.7 | 49.7 | 50.4 | 54.6 | 53.4 | 0.527 |
BMI (Mean, kg/m2) | 26.8 | 27.5 | 28.4 | 26.6 | 26.2 | 0.496 |
CH1 (n = 16) | PH2 (n = 357) | Post-I131(n = 20) | Thyroidectomy (benign) (n = 92) | Thyroidectomy (neoplasia) (n = 62) | P value* | |
---|---|---|---|---|---|---|
1CH: central hypothyroidism. 2PH: primary hypothyroidism. Dose/day: µg/day. Dose/weight/day: µg/kg/day. SD: standard deviation. (*) P value for comparison among the groups. Bonferroni’s post-hoc analysis: Hypothyroidism for malignant causes vs all other: P < 0.001; CH vs PH: P = 0.008; CH vs Post-I131: P = 0.001; CH vs post thyroidectomy: P < 0.001; PH vs Post I131: P = 0.319; PH vs thyroidectomy for benign causes: P < 0.001; Post I131vs thyroidectomy for benign causes: P = 1.0. | ||||||
Dose/day | 53.94 | 81.37 | 97.42 | 102.8 | 138.5 | < 0.0001 |
SD | 28.07 | 29.84 | 28.32 | 36.96 | 35.25 | - |
Dose/weight/day | 0.81 | 1.24 | 1.33 | 1.54 | 2.16 | < 0.0001 |
SD | 0.48 | 0.53 | 0.55 | 0.59 | 0.58 | - |
Years | ≤ 20 (n = 23) | 21 - 30(n = 36) | 31 - 40(n = 53) | 41 - 50 (n = 119) | 51 – 60 (n = 148) | 61 - 70 (n = 101) | > 70 (n = 62) | P value |
---|---|---|---|---|---|---|---|---|
Dose/day: µg/day. Dose/weight/day: µg/kg/day. SD: standard deviation. | ||||||||
Dose/day | 70.17 | 98.29 | 90 | 97.82 | 92.45 | 84.61 | 91.57 | 0.02 |
SD | 31.70 | 47.42 | 37.87 | 35.82 | 36.40 | 32.99 | 1.06 | - |
Dose/weight/day | 1.66 | 1.49 | 1.4 | 1.41 | 1.41 | 1.27 | 1.37 | 0.24 |
SD | 1.005 | 0.76 | 0.66 | 0.60 | 0.58 | 0.51 | 0.32 | - |
Variable | β Coefficient | P Value(*) |
---|---|---|
(*) a variable was considered independently significant only when the p value was below the threshold for Bonferroni’s correction (in this case P value < 0.01). | ||
BMI | -0.112 | 0.165 |
Weight | 0.229 | 0.004 |
Age | -0.024 | 0.550 |
Gender | 0.111 | 0.006 |
Etiology | 0.492 | < 0.001 |