J Endocrinol Metab

Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc

Journal website http://www.jofem.org

Original Article

Volume 6, Number 1, February 2016, pages 12-17

Plasma B-Type Natriuretic Peptide Levels May Increase Because of Fat Mass Loss by Metformin or Sodium-Glucose Transporter 2 Inhibitors Treatment

Figure 1. Changes in (a) fat mass and (b) visceral fat area (VFA) between baseline and 3 months after starting treatment with SGLT2 inhibitors.

**Table 1.** Anthropometric and Biochemical Parameters at Baseline, 3 and 6 Months After Metformin Administration
	Baseline	After 3 months	After 6 months	P value (baseline vs. after 3 months)	P value (after 3 months vs. after 6 months)	P value (baseline vs. after 6 months)
Data are expressed as mean ± SD. BNP: B-type natriuretic peptide; BMI: body mass index.
n (men/women)	15 (7/8)	-	-	-	-	-
Age (years)	54.9 ± 14	-	-	-	-	-
Weight (kg)	74.5 ± 15.6	68.6 ± 13.1	70.6 ± 14.6	0.068	0.114	0.043
BMI (kg/m²)	27.6 ± 6.2	26.4 ± 6	26.0 ± 5.7	0.068	0.144	0.043
Plasma glucose (mg/dL)	161.1 ± 59.4	133.9 ± 40.6	131.3 ± 44.7	0.074	0.754	0.078
HbA1c (%)	7.4 ± 1.2	6.7 ± 0.4	6.7 ± 0.5	0.001	0.886	0.004
Plasma BNP (pg/mL)	7.9 ± 7.9	17 ± 16.9	10.5 ± 8.5	0.012	0.272	0.109
Serum insulin	9.4 ± 5.2	-	6.6 ± 3.8	-	-	0.075
Skeletal muscle mass (kg)	26.7 ± 4.1	25.8 ± 4.3	26.7 ± 4.3	0.293	0.080	0.893
Fat mass (kg)	25.7 ± 10.3	23 ± 11.4	22.1 ± 11	0.046	0.144	0.043

Table 1. Anthropometric and Biochemical Parameters at Baseline, 3 and 6 Months After Metformin Administration

Baseline

After 3 months

After 6 months

P value (baseline vs. after 3 months)

P value (after 3 months vs. after 6 months)

P value (baseline vs. after 6 months)

Data are expressed as mean ± SD. BNP: B-type natriuretic peptide; BMI: body mass index.

n (men/women)

15 (7/8)

Age (years)

54.9 ± 14

Weight (kg)

74.5 ± 15.6

68.6 ± 13.1

70.6 ± 14.6

0.068

0.114

0.043

BMI (kg/m²)

27.6 ± 6.2

26.4 ± 6

26.0 ± 5.7

0.068

0.144

0.043

Plasma glucose (mg/dL)

161.1 ± 59.4

133.9 ± 40.6

131.3 ± 44.7

0.074

0.754

0.078

HbA1c (%)

7.4 ± 1.2

6.7 ± 0.4

6.7 ± 0.5

0.001

0.886

0.004

Plasma BNP (pg/mL)

7.9 ± 7.9

17 ± 16.9

10.5 ± 8.5

0.012

0.272

0.109

Serum insulin

9.4 ± 5.2

6.6 ± 3.8

0.075

Skeletal muscle mass (kg)

26.7 ± 4.1

25.8 ± 4.3

26.7 ± 4.3

0.293

0.080

0.893

Fat mass (kg)

25.7 ± 10.3

23 ± 11.4

22.1 ± 11

0.046

0.144

0.043

**Table 2.** Baseline Characteristics of Subjects Treated With SGLT2 Inhibitors
Baseline characteristics
Data are expressed as number or mean ± SD. SGLT2: sodium-glucose transporter 2; DPP4: dipeptidyl peptidase 4.
n	7
Sex (men/women)	3/4
Age (years)	52.1 ± 10.8
Duration of diabetes (years)	5.6 ± 5.5
Medication
Metformin	6
Pioglitazone	2
DPP4 inhibitors	3
Sulfonylurea	1
Insulin	1

Table 2. Baseline Characteristics of Subjects Treated With SGLT2 Inhibitors

Baseline characteristics

Data are expressed as number or mean ± SD. SGLT2: sodium-glucose transporter 2; DPP4: dipeptidyl peptidase 4.

Sex (men/women)

3/4

Age (years)

52.1 ± 10.8

Duration of diabetes (years)

5.6 ± 5.5

Medication

Metformin

Pioglitazone

DPP4 inhibitors

Sulfonylurea

Insulin

**Table 3.** Anthropometric and Biochemical Parameters at Baseline and 3 Months After SGLT2 Inhibitors Administration
	Baseline	After 3 months	P value
Data are expressed as mean ± SD. BNP: B-type natriuretic peptide; BMI: body mass index.
n (men/women)	7 (3/4)	-	-
Weight (kg)	85.4 ± 20.1	83.7 ± 20.3	0.063
BMI (kg/m²)	32.3 ± 6.7	31.6 ± 6.6	0.063
Plasma glucose (mg/dL)	151.0 ± 64.5	124.7 ± 24.2	0.108
HbA1c (%)	7.9 ± 1.9	7.2 ± 1.1	0.018
Plasma BNP (pg/mL)	8.8 ± 7.2	15.5 ± 14.3	0.018
Serum insulin	14.0 ± 5.8	11.5 ± 3.3	0.080

Table 3. Anthropometric and Biochemical Parameters at Baseline and 3 Months After SGLT2 Inhibitors Administration

Baseline

After 3 months

P value

Data are expressed as mean ± SD. BNP: B-type natriuretic peptide; BMI: body mass index.

n (men/women)

7 (3/4)

Weight (kg)

85.4 ± 20.1

83.7 ± 20.3

0.063

BMI (kg/m²)

32.3 ± 6.7

31.6 ± 6.6

0.063

Plasma glucose (mg/dL)

151.0 ± 64.5

124.7 ± 24.2

0.108

HbA1c (%)

7.9 ± 1.9

7.2 ± 1.1

0.018

Plasma BNP (pg/mL)

8.8 ± 7.2

15.5 ± 14.3

0.018

Serum insulin

14.0 ± 5.8

11.5 ± 3.3

0.080