Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 7, Number 5, October 2017, pages 141-145
Obstructive Sleep Apnea Syndrome Is Less Frequent in Patients With Well-Controlled Acromegaly Treated With Somatostatin Analogues, Pegvisomant or in Combination
Figures
Tables
Number/mean | Range | |
---|---|---|
Number | 29 | |
Female | 12 | |
Male | 17 | |
Age (years) | 49 ± 14 | 25 - 73 |
BMI (kg/m2) | 29.9 ± 5.4 | 20.8 - 29.9 |
Disease duration (years) | 13 ± 8 | 2 - 32 |
IGF-I (µg/L) | 184 ± 73 | 74 - 383 |
Well-controlled acromegaly | 29 (100%) | |
Surgery | 22 (76%) | |
Radiation + surgery | 7 (24%) |
Treatments/medications | AHI < 5 | AHI ≥ 5 | P |
---|---|---|---|
Age (years) | 47 ± 13 | 61 ± 9 | 0.037 |
M/F | 9/16 | 2/2 | n.s. |
BMI (kg/m2) | 30.0 ± 5.7 | 30.0 ± 3.0 | n.s. |
Disease duration (years) | 12 ± 8 | 16 ± 1 | 0.01 |
AHI | 2 ± 2 | 9 ± 4 | 0.05 |
Epworth sleepiness scale score | 6 ± 4 | 4 ± 2 | n.s. |
IGF-I (µg/L) | 187 ± 78 | 169 ± 30 | n.s. |
AHI < 5 | AHI ≥ 5 | |
---|---|---|
Number | 25 (87%) | 4 (13%) |
Previous treatment | ||
Surgery | 19 (76%) | 3 (75%) |
Radiation + surgery | 6 (24%) | 1 (25%) |
Current medication | ||
SSA | 9 (36%) | 2 (50%) |
Pegvisomant | 10 (40%) | 1 (25%) |
SSA + pegvisomant | 6 (24%) | 1 (25%) |