Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Original Article

Volume 8, Number 1, February 2018, pages 2-5


Evaluation of Bone Turnover in Patients With Type 1 Diabetes Mellitus

Tables

Table 1. Characteristics of Subjects
 
Md (Q1/Q3)T1DM n = 98Non-DM controls n = 82
M: male; F: female.
Sex (M:F)M : 41F : 57M : 39F : 43
Age (years)56 (51/61)58 (52/63)58 (51/64)56 (49/60)
Duration of DM (years)15 (11/20)18 (12/22)NANA
BMI (kg/m2 )25 (25/27)26(24/27)28(25/30)28 (26/32)
FPG (mmol/L)7.9 (6.7/9.7)6.6 (5.9/8.0)4.9 (4.5/5.1)5.0 (4.7/5.2)
HbA1C (%)7.2 (6.5/8.1)7.4 (6.3/8.8)5.0 (4.7/5.2)5.0 (4.8/5.1)
Ca2+1.17 (1.11/1.19)1.06 (0.98/1.12)1.19 (1.14/1.2)1.11(1.07/1.14)
Inorganic P5.6 (5.1/6.2)5.3 (4.9/5.9)5.2 (4.8/5.4)5.0 (4.6/5.4)
Mg2+1.8 (1.3/2.2)1.3 (1.1/1.7)1.8 (1.7/2.2)1.6 (1.2/1.9)
Creatinine (mg/dL)0.9 (0.7/1.05)0.8 (0.72/0.86)0.7 (0.62/0.91)0.7 (0.66/0.82)
eGFR (mL/min/1.73 m2)93 (75/103.5)82 (73/93.5)104 (88.5/110)93 (77/102.5)
Total cholesterol (mg/dL)185 (165/216)198 (157/229)163 (157/192)168 (158/206)

 

Table 2. Bone Turnover Markers and BMD Characteristics of Subjects
 
Md (Q1/Q3) %T1DM n = 98Non-DM controls n = 82
*P < 0.05, **P < 0.005, ***P < 0.001 compared with patients of the control group; "P < 0.05, ""P < 0.005, """P < 0.001 compared with female patients of the same group.
Sex (M:F)M : 41F:57M : 39F : 43
ALP ( IU/L)117.1" (101.4/146.8)102.2 (89.6/138.1)134.1" (95.9/152.1)105.1 (87.8/133.8)
P1NP (ng/mL)41.31"" (33.22/49.06)33.16*** (28.16/41.50)45.95 (30.20/59.44)47.99 (36.98/60.77)
b-CTх (ng/mL)0.412* (0.328/0.557)0.508 (0.368/0.648)0.338"" (0.261/0.45)0.442 (0.350/0.533)
Spine Т-score (L1-L4)-1.4***"" (-2.2/-0.9)-2.4** (-3.0/-1.5)-0.1""" (-0.6/0.7)-1.0 (-2.1/-0.4)
22 (54%)41 (72%)5 (13%)16 (37%)
Proximal femur Т-score-0.7*"" (-1.4/-0.2)-2.1*** (-2.4/-1.4)-0.1 (-0.7/0.8)-0.7 (-1.6/0.2)
11 (27%)24 (42%)4 (10%)13 (30%)
Femoral neck T-score-1.15**" (-1.9/-0.7)-2.3** (-2.7/-1.3)-0.0 (-1.0/0.6)-0.85 (-1.9/0.3)
17 (41%)23 (40%)6 (15%)15 (30%)
Spine Z-score (L1-L4)-0.75*** (-1.8/0.07)-0.9** (-2.1/-0.3)1.1"" (0.3/1.4)-0.1 (-0.7/0.8)
12 (29%)21 (37%)3 (8%)6 (14%)
Proximal femur Z-score-0.15" (-0.9/0.5)-1.2*** (-1.4/-0.4)0.4 (0.0/1.2)-0.05 (-0.7/0.8)
6 (15%)16 (28%)3 (8%)7 16(%)
Femoral neck Z-score-0.1*" (-0.8/0.4)-1.0* (-1.4/-0.1)0.4 (-0.1/1.5)-0.05 (-0.7/1.1)
5 (12%)15 (26%)2 (5%)6 (14%)

 

Table3. A Comparison of the Distribution of T-score BMD Reduction According to WHO Classification Between the Lowest Indices of Both Hips and Spine at Patients With T1DM and Control Group
 
%T1DM n = 98Non-DM controls n = 82
Sex (M : F)M : 41F : 57M : 39F : 43
L1 - L27 (17%)10 (17.5 %)1 (2.5%)5 (12%)
L3 - L415 (36.5%)31 (54%)4 (10%)11 (25.5%)
Left hip10 (24%)13 (23%)5 (13%)9 (21%)
Right hip7 (17%)10 (17.5%)1 (2.5%)6 (14%)