Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Original Article

Volume 2, Number 3, June 2012, pages 120-127


Interleukin-6, Tumor Necrosis Factor a and Metabolic Disorders in Youth

Tables

Table 1. Comparison of the Obese Children and Adolescents to the Control Group
 
Group ΑGroup CP
Patients (n)54 (28 female) fffefemale)40 (22 female)
Age (years)11.2 ± 2.610.8 ± 2.80.402
Weight (kg)71.0 ± 18.835.8 ± 13.0< 0.001
ΒΜΙ (kg/m2)30.7 ± 3.718.3 ± 2.9< 0.001
WC (cm)104.0 ± 12.363.6 ± 9.3< 0.001
Fasting Glucose (mg/dL) GlucosegLUCOSEGlucose(mg/dl)98.1 ± 10.384.0 ± 7.1< 0.001
Fasting Insulin (µU/mL)25.0 ± 14.48.7 ± 4.2< 0.001
HOMA-IR6.2 ± 4.01.8 ± 0.9< 0.001
IL-6 (pg/mL)2.4 ± 1.91.0 ± 0.5< 0.001
TNFα (pg/mL)2.1 ± 1.22.0 ± 0.60.805

 

Table 2. Comparison of the Overweight Children and Adolescents to the Control Group
 
Group ΒGroup CP
Patients (n)50 (30 female)40 (22 female)
Age (years)11.8 ± 1.910.8 ± 2.80.06
Weight (kg)60.1 ± 10.535.8 ± 13.0< 0.001
BΜΙ (kg/m2)25.7 ± 1.718.3 ± 2.9< 0.001
WC (cm)90.1 ± 6.763.6 ± 9.3< 0.001
Fasting Glucose (mg/dL)93.0 ± 6.984.0 ± 7.1< 0.001
Fasting Insulin (µU/mL)17.1 ± 9.98.7 ± 4.2< 0.001
HOMA-IR3.9 ± 2.31.8 ± 0.9< 0.001
IL-6 (pg/mL)1.5 ± 1.21.0 ± 0.50.027
TNFα (pg/mL)2.0 ± 1.02.0 ± 0.60.997

 

Table 3. Comparison Between Obese and Overweight Children and Adolescents
 
Group AGroup BP
Patients (n)54 (28 female)50 (30 female)
Age (years)11.2 ± 2.611.8 ± 1.90.207
Weight (kg)71.0 ± 18.860.1 ± 10.50.001
BΜΙ (kg/m2)30.7 ± 3.725.7 ± 1.7< 0.001
WC (cm)104.0 ± 12.390.1 ± 6.7< 0.001
Fasting Glucose (mg/dL)98.1 ± 10.393.0 ± 6.90.004
Fasting Insulin (µU/mL)25.0 ± 14.417.1 ± 9.90.001
HOMA-IR6.2 ± 4.03.9 ± 2.30.001
IL-6 (pg/mL)2.4 ± 1.91.5 ± 1.20.014
TNFα (pg/mL)2.1 ± 1.22.0 ± 1.00.834

 

Table 4. Comparison Between Obese and Overweight Children and Adolescents With and Without MS
 
MSWithout ΜSP
Patients (n)2183
Age (years)11.3 ± 2.511.6 ± 2.30.578
Weight (kg)73.1 ± 21.464.2 ± 14.20.082
BΜΙ (kg/m2)31.4 ± 4.727.5 ± 3.20.002
WC (cm)102.0 ± 12.593.2 ± 9.20.005
Fasting Glucose (mg/dL)100.0 ± 9.794.6 ± 8.70.015
Fasting Insulin (µU/mL)29.9 ± 17.319.0 ± 10.80.011
HOMA-IR7.6 ± 5.04.5 ± 2.70.012
IL-6 (pg/mL)2.9 ± 1.91.7 ± 1.50.013
TNFα (pg/mL)2.2 ± 1.02.0 ± 1.10.641

 

Table 5. Comparison Between Obese and Overweight Children and Adolescents With and Without Prediabetes
 
PrediabetesNo PrediabetesP
Patients (n)3569
Age (years)11.4 ± 2.311.6 ± 2.40.670
Weight (kg)68.2 ± 16.564.8 ± 16.10.322
BΜΙ (kg/m2)29.4 ± 4.327.8 ± 3.60.042
WC (cm)98.0 ± 11.793.4± 9.60.038
Fasting Glucose (mg/dL)104.3 ± 9.191.3 ± 5.3< 0.001
Fasting Insulin (µU/mL)25.8 ± 15.619.0 ± 11.00.012
HOMA-IR6.8 ± 4.54.3 ± 2.50.004
IL-6 (pg/mL)1.9 ± 1.52.0 ± 1.80.805
TNFα (pg/mL)2.3 ± 1.02.0 ± 1.10.205

 

Table 6. Comparison Between Obese and Overweight Children and Adolescents With and Without NAFLD
 
NΑFLDNo NΑFLDP
Patients (n)3371
Age (years)11.0 ± 2.311.7 ± 2.30.158
Weight (kg)67.1 ± 19.465.5 ± 14.60.643
BΜΙ (kg/m2)29.5 ± 4.827.8 ± 3.30.068
WC (cm)97.4 ± 12.493.9 ± 9.40.154
Fasting Glucose (mg/dL)94.7 ± 10.596.1 ± 8.50.460
Fasting Insulin (µU/mL)24.4 ± 13.919.7 ± 12.40.089
HOMA-IR5.8 ± 3.74.8 ± 3.40.136
IL-6 (pg/mL)2.6 ± 2.21.7 ± 1.40.109
TNFα (pg/mL)2.7 ± 1.11.9 ± 1.00.005