Figure 1. The proposed hypothesis for the development of autoimmune hypophysitis in HCV infection and IFN-based therapy. IL-6: Interleukin-6; IFN: Interferon; MHC-II: major histocompatability complex-II; TH: T helper.
| Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
| Journal website http://www.jofem.org |
Case Report
Volume 2, Number 4-5, October 2012, pages 190-194
Pituitary Disease in Chronic Hepatitis C Infection and Interferon-alpha Related Therapy: Two Case Reports
Figure
Table
| Authors and Year of publications | Gender:Age | Pituitary Antibody status | MRI findings | Treatment modality | Panhypopituitarism and therapy | Reversibility |
|---|---|---|---|---|---|---|
| 1. Sakane et al, 1995 | F:44 | YES: GH3 cell | Normal | IFN-α monotherapy for 3 months | Y: Hydrocortisone and Thyroxine | Yes, after 11 months |
| 2. Concha et al, 2003 | M:39 | NO:Normal Human Pituitary Tissues | Normal | IFN-α and RBV for 1 year | Y: Testosterone and Growth hormone | No |
| 3. Chan et al, 2004 | F:30 (HBV infection) | Not done | Anterior pituitary cyst | IFN-α monotherapy for 3 years | Y: Hydrocortisone, Oestrogen and Thyroxine | No |
| 4. Ridruejo et al, 2006 | F:54 | Not done | Not done | IFN-α and RBV for 48 weeks | Y: No therapy | Yes, transient |
| 5. Our case 1 | M:34 | Not available | Normal | IFN-α and RBV for 48 weeks | Y: Hydrocortisone | Unknown. Lost to follow up |
| 6. Our case 2 | M:45 | Not available | Normal | Untreated | Y: Hydrocortisone, Testosterone and Thyroxine | No |