Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Letter to the Editor
Volume 3, Number 3, June 2013, pages 78-80
Effects of Sitagliptin May Depend on Clinical and Laboratory Data at the Baseline
Tables
Subjects studied (n) | Data before 6 month-use of sitagliptin | Data after 6 month-use of sitagliptin | P value | |
---|---|---|---|---|
Presented values indicate mean ± S.D. Statistical analyses have been done by the paired T test; e-GFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL-C, low-density lipoprotein-cholesterol; NS, not statistically significant; TG, triglyceride. | ||||
Body weight (kg) | 110 | 71.6 ± 15.2 | 70.7 ± 15.5 | < 0.01 |
Systolic blood pressure (mmHg) | 124 | 126.1 ± 15.3 | 124.6 ± 13.2 | NS |
Diastolic blood pressure (mmHg) | 124 | 71.7 ± 12.2 | 72.7 ± 10.6 | NS |
Plasma glucose (mg/dL) | 154 | 190.9 ± 71.6 | 176.2 ± 67.8 | < 0.01 |
Hemoglobin A1c (%) | 132 | 7.8 ± 1.3 | 7.2 ± 1.2 | < 0.05 |
Serum LDL-C (mg/dL) | 129 | 105.8 ± 30.3 | 103.2 ± 28.8 | NS |
Serum TG (mg/dL) | 144 | 192.7 ± 126.7 | 187.3 ± 136.8 | NS |
Serum HDL-C (mg/dL) | 136 | 48.9 ± 13.2 | 47.7 ± 11.0 | NS |
e-GFR (mL/min./1.73m2) | 155 | 80.5 ± 24.7 | 79.5 ± 25.9 | NS |
Subjects studied (n) | Data before 6 month-use of sitagliptin | Data after 6 month-use of sitagliptin | P value | |
---|---|---|---|---|
Presented values indicate mean ± S.D. Statistical analyses have been done by the Wilcoxon signed-rank test; e-GFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL-C, low-density lipoprotein-cholesterol; NS, not statistically significant; TG, triglyceride. | ||||
Body weight (kg) | 30 | 56.3 ± 11.8 | 55.7 ± 10.8 | NS |
Systolic blood pressure (mmHg) | 45 | 128.4 ± 16.1 | 126.9 ± 14.6 | NS |
Diastolic blood pressure (mmHg) | 45 | 65.4 ± 10.2 | 65.2 ± 10.0 | NS |
Plasma glucose (mg/dL) | 42 | 167.2 ± 54.6 | 173.2 ± 65.1 | NS |
Hemoglobin A1c (%) | 37 | 7.3 ± 1.1 | 6.8 ± 1.0 | < 0.05 |
Serum LDL-C (mg/dL) | 37 | 101.6 ± 24.3 | 101.9 ± 20.5 | NS |
Serum TG (mg/dL) | 40 | 126.1 ± 81.5 | 126.0 ± 84.1 | NS |
Serum HDL-C (mg/dL) | 41 | 55.0 ± 17.5 | 53.6 ± 17.7 | NS |
e-GFR (mL/min./1.73m2) | 45 | 66.5 ± 19.8 | 63.2 ± 18.5 | NS |
People who are 74 years old or younger | People who are 75 years old or older | P value | |
---|---|---|---|
Presented values indicate mean ± S.D. Statistical analyses have been done by the Z test; e-GFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL-C, low-density lipoprotein-cholesterol; NS, not statistically significant; TG, triglyceride. | |||
Body weight (kg) | -0.9 ± 3.9 | -0.6 ± 2.7 | < 0.001 |
Systolic blood pressure (mmHg) | -1.5 ± 15.3 | -1.4 ± 23.0 | < 0.05 |
Diastolic blood pressure (mmHg) | +1.0 ± 12.2 | -0.2 ± 13.0 | NS |
Plasma glucose (mg/dL) | -14.8 ± 68.9 | +6.0 ± 74.0 | < 0.05 |
Hemoglobin A1c (%) | -0.6 ± 1.0 | -0.4 ± 0.7 | < 0.001 |
Serum LDL-C (mg/dL) | -2.5 ± 26.7 | -9.0 ± 33.2 | < 0.05 |
Serum TG (mg/dL) | -5.4 ± 141.2 | -0.1 ± 44.2 | NS |
Serum HDL-C (mg/dL) | -1.2 ± 8.3 | -1.4 ± 10.1 | < 0.001 |
e-GFR (mL/min./1.73m2) | -1.0 ± 12.5 | -3.2 ± 9.4 | < 0.01 |