J Endocrinol Metab

Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc

Journal website http://www.jofem.org

Original Article

Volume 3, Number 4-5, October 2013, pages 105-110

Effects of Metformin on Thyroid Function in Patients of Subclinical Hypothyroidism

**Table 1.** Baseline Characteristics of Group 1 and Group 2
Baseline Characteristics	Group 1 (n = 23)	Group 2 (n = 7)	P value
Age (years)	36.70 ± 7.32	39 ± 13.68	0.09
Weight (kg)	70.96 ± 9.22	62.43 ± 7.79	0.02
BMI (kg/m²)	29.39 ± 4.56	24.29 ± 2.81	0.004
Waist Circumference (cm)	91.43 ± 8.58	82.14 ± 2.41	0.001
Body fat (%)	36.38 ± 4.39	31.86 ± 5.70	0.02
fT3 (2.4 - 4.2 pg/mL)	2.83 ± 0.65	3.14 ± 0.38	0.21
fT4 (0.8 - 1.7 ng/dL)	1.04 ± 0.21	1.00 ± 0.14	0.3
TSH (0.34 - 4.25 mIU/L)	7.39 ± 1.37	7.29 ± 1.38	0.83
Anti TPO Ab (< 60 IU/mL)	45.17 ± 19.55	2186.29 ± 2110.00	< 0.001
S. Insulin (mIU/L)	15.30 ± 3.62	8.29 ± 3.82	< 0.01
HOMA-IR	3.20 ± 0.84	2.00 ± 1.00	0.02
TG (mg/dL)	135.91 ± 36.34	134.00 ± 40.17	0.71
Cholesterol (mg/dL)	174.17 ± 18.55	180.86 ± 27.55	0.76
HDL (mg/dL)	42.04 ± 4.56	42.71 ± 2.93	0.43
LDL (mg/dL)	109.22 ± 17.89	114.71 ± 24.63	0.69
VLDL (mg/dL)	22.87 ± 4.90	23.57 ± 8.92	0.91

Table 1. Baseline Characteristics of Group 1 and Group 2

Baseline Characteristics

Group 1 (n = 23)

Group 2 (n = 7)

P value

Age (years)

36.70 ± 7.32

39 ± 13.68

0.09

Weight (kg)

70.96 ± 9.22

62.43 ± 7.79

0.02

BMI (kg/m²)

29.39 ± 4.56

24.29 ± 2.81

0.004

Waist Circumference (cm)

91.43 ± 8.58

82.14 ± 2.41

0.001

Body fat (%)

36.38 ± 4.39

31.86 ± 5.70

0.02

fT3 (2.4 - 4.2 pg/mL)

2.83 ± 0.65

3.14 ± 0.38

0.21

fT4 (0.8 - 1.7 ng/dL)

1.04 ± 0.21

1.00 ± 0.14

0.3

TSH (0.34 - 4.25 mIU/L)

7.39 ± 1.37

7.29 ± 1.38

0.83

Anti TPO Ab (< 60 IU/mL)

45.17 ± 19.55

2186.29 ± 2110.00

< 0.001

S. Insulin (mIU/L)

15.30 ± 3.62

8.29 ± 3.82

< 0.01

HOMA-IR

3.20 ± 0.84

2.00 ± 1.00

0.02

TG (mg/dL)

135.91 ± 36.34

134.00 ± 40.17

0.71

Cholesterol (mg/dL)

174.17 ± 18.55

180.86 ± 27.55

0.76

HDL (mg/dL)

42.04 ± 4.56

42.71 ± 2.93

0.43

LDL (mg/dL)

109.22 ± 17.89

114.71 ± 24.63

0.69

VLDL (mg/dL)

22.87 ± 4.90

23.57 ± 8.92

0.91

**Table 2.** Showing Anthropometric Parameters in Group 1 and 2 at Baseline and at 12 Weeks
Anthropometric parameters	Group 1 (n = 23)	Group 2 (n = 7)
Body wt (kg)	70.96 ± 9.22	69.17 ± 8.77 (P < 0.01)	62.43 ± 7.79	62.14 ± 7.54 (P = 0.03)
BMI (kg/m²)	29.44 ± 4.55	28.65 ± 4.44 (P < 0.01)	24.27 ± 2.73	24.17 ± 2.65 (P = 0.03)
WC (cm)	91.43 ± 8.58	90.17 ± 8.36 (P < 0.01)	82.14 ± 2.41	81.35 ± 2.37 (P = 0.02)
BF (%)	36.43 ± 4.38	35.17 ± 4.42 (P = 0.01)	31.80 ± 5.42	31.30 ± 5.24 (P = 0.001)

Table 2. Showing Anthropometric Parameters in Group 1 and 2 at Baseline and at 12 Weeks

Anthropometric parameters

Group 1 (n = 23)

Group 2 (n = 7)

Baseline

12 WKS

Baseline

12 WKS

Body wt (kg)

70.96 ± 9.22

69.17 ± 8.77 (P < 0.01)

62.43 ± 7.79

62.14 ± 7.54 (P = 0.03)

BMI (kg/m²)

29.44 ± 4.55

28.65 ± 4.44 (P < 0.01)

24.27 ± 2.73

24.17 ± 2.65 (P = 0.03)

WC (cm)

91.43 ± 8.58

90.17 ± 8.36 (P < 0.01)

82.14 ± 2.41

81.35 ± 2.37 (P = 0.02)

BF (%)

36.43 ± 4.38

35.17 ± 4.42 (P = 0.01)

31.80 ± 5.42

31.30 ± 5.24 (P = 0.001)

**Table 3.** Showing Biochemical Parameters in Group 1 and 2 at Baseline and at 12 Weeks
Biochemical parameter	Group 1 (n = 23)	Group 2 (n = 7)
fT3 (pg/mL)	2.76 ± 0.53	2.79 ± 0.55 (P = 0.27)	3.18 ± 0.36	2.73 ± 0.31 (P = 0.02)
fT4 (ng/dL)	1.11 ± 0.19	1.10 ± 0.28 (P = 0.75)	1.03 ± 0.18	0.88 ± 0.12 (P = 0.02)
TSH (mIU/L)	7.33 ± 1.37	5.00 ± 1.38 (P < 0.01)	7.05 ± 1.33	8.55 ± 1.08 (P = 0.003)
FPG (mg/dL)	84.96 ± 10.59	80.74 ± 6.95 (P = 0.07)	81.43 ± 3.21	77.14 ± 4.98 (P = 0.07)
S.INSULIN (mU/L)	15.30 ± 3.63	8.28 ± 2.76 (P < 0.01)	8.30 ± 3.82	5.66 ± 2.51 (P = 0.004)
HOMA-IR	3.20 ± 0.84	1.65 ± 0.57 (P < 0.01)	1.95 ± 0.86	1.29 ± 0.66 (P = 0.001)
TG (mg/dL)	135.93 ± 36.36	127.04 ± 32.63 (P < 0.01)	133.99 ± 40.02	127.54 ± 42.74 (P = 0.02)
CHOLESTEROL (mg/dL)	174.17 ± 18.55	168.78 ± 16.58 (P < 0.01)	180.93 ± 27.62	174.06 ± 17.0 (P = 0.16)
HDL (mg/dL)	42.04 ± 4.56	43.26 ± 3.57 (P = 0.002)	42.71 ± 2.96	43.71 ± 2.98 (P = 0.03)
LDL (mg/dL)	109.22 ± 17.89	103.17 ± 16.28 (P < 0.01)	114.67 ± 24.72	107.69 ± 19.23 (P = 0.04)
VLDL (mg/dL)	22.87 ± 4.89	23.09 ± 5.5 (P = 0.75)	23.54 ± 8.83	22.66 ± 6.36 (P = 0.71)

Table 3. Showing Biochemical Parameters in Group 1 and 2 at Baseline and at 12 Weeks

Biochemical parameter

Group 1 (n = 23)

Group 2 (n = 7)

Baseline

12 WKS

Baseline

12 WKS

fT3 (pg/mL)

2.76 ± 0.53

2.79 ± 0.55 (P = 0.27)

3.18 ± 0.36

2.73 ± 0.31 (P = 0.02)

fT4 (ng/dL)

1.11 ± 0.19

1.10 ± 0.28 (P = 0.75)

1.03 ± 0.18

0.88 ± 0.12 (P = 0.02)

TSH (mIU/L)

7.33 ± 1.37

5.00 ± 1.38 (P < 0.01)

7.05 ± 1.33

8.55 ± 1.08 (P = 0.003)

FPG (mg/dL)

84.96 ± 10.59

80.74 ± 6.95 (P = 0.07)

81.43 ± 3.21

77.14 ± 4.98 (P = 0.07)

S.INSULIN (mU/L)

15.30 ± 3.63

8.28 ± 2.76 (P < 0.01)

8.30 ± 3.82

5.66 ± 2.51 (P = 0.004)

HOMA-IR

3.20 ± 0.84

1.65 ± 0.57 (P < 0.01)

1.95 ± 0.86

1.29 ± 0.66 (P = 0.001)

TG (mg/dL)

135.93 ± 36.36

127.04 ± 32.63 (P < 0.01)

133.99 ± 40.02

127.54 ± 42.74 (P = 0.02)

CHOLESTEROL (mg/dL)

174.17 ± 18.55

168.78 ± 16.58 (P < 0.01)

180.93 ± 27.62

174.06 ± 17.0 (P = 0.16)

HDL (mg/dL)

42.04 ± 4.56

43.26 ± 3.57 (P = 0.002)

42.71 ± 2.96

43.71 ± 2.98 (P = 0.03)

LDL (mg/dL)

109.22 ± 17.89

103.17 ± 16.28 (P < 0.01)

114.67 ± 24.72

107.69 ± 19.23 (P = 0.04)

VLDL (mg/dL)

22.87 ± 4.89

23.09 ± 5.5 (P = 0.75)

23.54 ± 8.83

22.66 ± 6.36 (P = 0.71)