| Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
| Journal website http://www.jofem.org |
Original Article
Volume 6, Number 4, August 2016, pages 109-115
Demographic and Clinical Factors Associated With the Appropriate Target Thyroid-Stimulating Hormone Values in Patients With Primary Hypothyroidism Treated With Levothyroxine
Tables
| Variables | Data* |
|---|---|
| *Data are presented as N (%), mean ± SD or median (min. - max.), according to the variable. “N” indicates the number of patients. | |
| Male/female, N (%) | 11 (6.32%)/163 (93.68%) |
| Age (years) | 55.53 ± 14.13 |
| Disease duration (months) | 48 (3 - 600) |
| TSH value (mIU/L) | 2.09 (0.004 - 40.50) |
| Free T4 value (ng/dL) | 1.19 (0.41 - 2.22) |
| Ethnicity (n = 173) | |
| Caucasians | 112 (64.74%) |
| Non-Caucasians | 61 (35.26%) |
| Education (n = 173) | |
| Illiterate | 28 (16.18%) |
| Until fourth grade of elementary school | 48 (27.75%) |
| Until eight grade of elementary school | 38 (21.96%) |
| High school | 43 (24.86%) |
| Superior diploma | 16 (9.25%) |
| Monthly income (n = 168) | |
| < 2 minimum wages | 99 (58.93%) |
| > 2 minimum wages | 69 (41.07%) |
| Etiology (n = 174) | |
| Autoimmune | 73 (41.95%) |
| Thyroidectomy due to cancer | 51 (29.31%) |
| Thyroidectomy due to BNTD | 50 (28.74%) |
| Overall etiology (n = 174) | |
| Benign | 123 (70.69%) |
| Malignant | 51 (29.31%) |
| Benign | Malignant | P-value | |
|---|---|---|---|
| Age (years) | 57.37 ± 13.73 | 51.08 ± 14.22 | 0.008 |
| Disease duration (months) | 60 (3 - 600) | 24 (3 - 288) | < 0.001 |
| TSH value (mIU/L) | 2.56 (0.004 - 40.50) | 0.89 (0.004 - 36.29) | 0.010 |
| FT4 value (ng/dL) | 1.17 (0.57 - 1.83) | 1.36 (0.41 - 2.22) | 0.018 |
| Adequate | Inadequate | P-value | |
|---|---|---|---|
| Etiology | 0.08 | ||
| Benign | 73 (76.04%) | 50 (64.10%) | |
| Malignant | 23 (23.96%) | 28 (35.90%) | |
| Sex | 0.96 | ||
| Male | 6 (6.25%) | 5 (6.41%) | |
| Female | 90 (93.75%) | 73 (93.59%) | |
| Ethnicity | 0.78 | ||
| Caucasians | 63 (65.63%) | 49 (63.64%) | |
| Non-Caucasians | 33 (34.37%) | 28 (36.36%) | |
| Education | 0.99 | ||
| Illiterate | 16 (16.84%) | 12 (15.38%) | |
| Up to fourth grade of elementary school | 26 (27.37%) | 22 (28.21%) | |
| Up to eighth grade of elementary school | 20 (21.05%) | 18 (23.08%) | |
| High school | 24 (25.26%) | 19 (24.36%) | |
| Superior diploma | 9 (9.48%) | 7 (8.97%) | |
| Monthly income | 0.28 | ||
| < 2 minimum wages | 52 (55.32%) | 47 (63.51%) | |
| > 2 minimum wages | 42 (44.68%) | 27 (36.49%) | |
| Use of the same LT-4 brand | 0.01 | ||
| Yes | 87 (90.63%) | 59 (76.62%) | |
| No | 9 (9.37%) | 18 (23.38%) | |
| LT-4 brand | 0.55 | ||
| Generic | 13 (14.94%) | 11 (18.64%) | |
| Name-brand | 74 (85.06%) | 48 (81.36%) | |
| Fasting | 0.22 | ||
| Yes | 92 (95.83%) | 71 (91.03%) | |
| No | 4 (4.17%) | 7 (8.97%) | |
| Current smoking | 0.04 | ||
| Yes | 1 (0.01%) | 6 (7.69%) | |
| No | 95 (99.99%) | 72 (92.31%) |