Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
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Original Article

Volume 7, Number 2, April 2017, pages 55-60

Calcium Mediates the Phosphaturia in Hypercalcemia of Malignancy

Figures

Figure 1.
Figure 1. Variabilities in biochemical measurements before and after hydration therapy in hypercalcemia of malignancy.
Figure 2.
Figure 2. Schematic presentation of calcium mediated regulation of tubular reabsorption of phosphate and bicarbonate ions in renal tubules. CaSR: calcium sensing receptor; PTH: parathyroid hormone.

Table

Table 1. Variabilities in Biochemical Measurements Before and After Hydration Therapy in Hypercalcemia of Malignancy
 
Patient no.Calcium (mg/dL)Phosphate (mg/dL)PTHrP (pmol/L)TRP (%)
BeforeAfterBeforeAfterBeforeAfterBeforeAfter
NS: non-significant. *After exclusion of patients no. 3 and 7; P < 0.01.
111.59.63.35.44.13.770.475.3
215.412.03.13.44.03.067.870.6
315.513.42.92.514.614.060.851.0
417.812.31.31.12.32.464.488.6
513.110.62.32.28.68.964.579.6
611.39.63.94.31.81.784.688.4
713.810.21.42.14.86.381.689.8
813.48.94.93.72.71.964.783.4
913.010.52.62.53.94.867.0474.0
Mean ± SD13.9 ± 2.110.8 ± 1.482.86 ± 1.443.02 ± 1.315.20 ± 4.045.19 ± 4.0369.54 ± 8.1677.85 ± 12.24
P value< 0.001NSNS< 0.05*