Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Case Report
Volume 9, Number 1-2, April 2019, pages 33-36
Two Cases of Mitochondrial Diabetes in Which Pancreatic Beta-Cell Function and Neuropathy Were Improved by Glucagon-Like Peptide-1 Receptor Agonist Therapy
Tables
Patient 1 | Patient 2 | |
---|---|---|
CPI: fasting C-peptide/fasting blood glucose × 100; eGFR: estimated glomerular filtration rate. | ||
Gender | Female | Female |
Age (years) | 36 | 44 |
Duration of diabetes mellitus (years) | 9 | 24 |
BMI (kg/m2) | 25.9 | 15.9 |
Fasting plasma glucose (mg/dL) | 119 | 163 |
HbA1c (%) | 8.1 | 8.8 |
Serum C-peptide (ng/dL) | 0.91 | 0.39 |
CPI | 1.08 | 0.24 |
Urinary C-peptide (µg/day) | 26.0 | 13.5 |
Diabetic complication | Only neuropathy | Only neuropathy |
Systolic blood pressure (mm Hg) | 163 | 98 |
Diastolic blood pressure (mm Hg) | 98 | 60 |
LDL-cholesterol (mg/dL) | 110 | 105 |
HDL-cholesterol (mg/dL) | 37 | 51 |
Triglyceride (mg/dL) | 129 | 62 |
AST (U/L) | 16 | 14 |
ALT (U/L) | 10 | 10 |
γ-GTP (U/L) | 26 | 20 |
eGFR (mL/min/1.73m2) | 105.7 | 92.5 |
Na (mmol/L) | 137 | 139 |
K (mmol/L) | 3.7 | 3.6 |
Cl (mmol/L) | 110 | 109 |
Lactate (mg/dL) | 18 | 31 |
Pyruvate (mg/dL) | 0.89 | 0.82 |
Lactate/pyruvate | 20.2 | 37.8 |
Diabetic treatment | Insulin | Insulin |
Daily insulin dose (unit) | 42 | 41 |
Vibration sensation of legs (s: right/left) | 8/9 | 4/6 |
Symptom of neuropathy | Numbness | Numbness and pain |
Familial history of mitochondrial disorder | MELAS (mother) | Not revealed |
Before commencing liraglutide | One year after commencing liraglutide | |
---|---|---|
CPI: fasting C-peptide/fasting blood glucose × 100. | ||
Patient 1 | ||
Fasting plasma glucose (mg/dL) | 119 | 114 |
HbA1c (%) | 8.1 | 7.4 |
CPI | 1.08 | 1.27 |
Daily insulin dose (unit) | 42 | 15 |
Daily liraglutide dose (mg) | 0 | 0.9 |
Vibration sensation of legs (s: right/left) | 8/9 | 13/13 |
Symptom of neuropathy | Numbness | None |
Patient 2 | ||
Fasting plasma glucose (mg/dL) | 163 | 111 |
HbA1c (%) | 8.8 | 8.2 |
CPI | 0.24 | 0.49 |
Daily insulin dose (unit) | 41 | 14 |
Daily liraglutide dose (mg) | 0 | 0.9 |
Vibration sensation of legs (s: right/left) | 4/6 | 8/8 |
Symptom of neuropathy | Numbness and pain | Slight pain |