Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 1, Number 5, December 2011, pages 220-226
Simultaneous Melatonin Administration Effectively Deprograms the Negative Influence of Neonatal Hypothyroidism on Immature Follicles but not on Mature Follicles and Body and Ovarian Weights
Figure
Tables
Treatment | Body weight | Absolute ovary weight | Relative ovary weight | ||||||
---|---|---|---|---|---|---|---|---|---|
22 days | 45 days | 90 days | 22 days | 45 days | 90 days | 22 days | 45 days | 90 days | |
C: Control; HPOT + MT: Melatonin treated Hypothyroid. Values expressed as mean ± SEM of six animals; aP < 0.01; bP < 0.005; cP < 0.0005. | |||||||||
C | 51.33 ± 1.87 | 136.66 ± 4.17 | 226.16 ± 9.57 | 0.024 ± 0.0003 | 0.062 ± 0.0069 | 0.076 ± 0.007 | 0.046 ± 0.0006 | 0.045 ± 0.0015 | 0.034 ± 0.0025 |
HPOT + MT | 30.83 ± 0.47c | 82.00 ± 0.93c | 166.83 ± 4.47c | 0.014 ± 0.0012c | 0.026 ± 0.0022c | 0.048 ± 0.005b | 0.047 ± 0.0043 | 0.031 ± 0.0022c | 0.028 ± 0.0031 |
Treatment | Age in Days | Follicle type | Ovarian Volume (mm3) | |||||
---|---|---|---|---|---|---|---|---|
Primordial | Primary | Secondary | Antral | CL | Atretic | |||
C: Control; HPOT + MT: Melatonin treated Hypothyroid. Values expressed as mean ± SEM of six animals; aP < 0.01; bP < 0.005; cP < 0.0005. | ||||||||
C | 22 | 821 ± 48 | 531 ± 25 | 350 ± 20 | 181 ± 04 | - | 10 ± 0.8 | 0.58 |
45 | 426 ± 17 | 162 ± 11 | 245 ± 10 | 142 ± 08 | - | 29 ± 02 | 0.68 | |
90 | 300 ± 13 | 168 ± 08 | 96 ± 04 | 72 ± 05 | 48 ± 05 | 36 ± 03 | 1.31 | |
HPOT + MT | 22 | 678 ± 36 | 523 ± 29 | 417 ± 24 | 73 ± 05c | - | 166 ± 21c | 0.41c |
45 | 452 ± 23 | 239 ± 19b | 298 ± 17a | 93 ± 09b | - | 209 ± 18c | 0.50c | |
90 | 339 ± 16 | 177 ± 13 | 159 ± 09c | 58 ± 03 | 42 ± 04 | 221 ± 26c | 0.87c |
Treatment | Estradiol | Progesterone | ||||
---|---|---|---|---|---|---|
22 days | 45 days | 90 days | 22 days | 45 days | 90 days | |
C: Control; HPOT + MT: Melatonin treated Hypothyroid. Values expressed as mean± SEM of six animals; aP < 0.01; bP < 0.005; cP < 0.0005. | ||||||
C | 2.04 ± 0.31 | 7.83 ± 0.75 | 13.07 ± 1.55 | 4.75 ± 0.68 | 21.75 ± 2.39 | 31.59 ± 4.36 |
HPOT + MT | 3.10 ± 0.92 | 5.68 ± 0.52 | 9.39 ± 1.84 | 7.80 ± 0.35c | 21.75 ±1.39 | 20.27 ± 3.47 |
Treatment | T3 | T4 | ||||
---|---|---|---|---|---|---|
22 days | 45 days | 90 days | 22 days | 45 days | 90 days | |
C: Control; HPOT + MT: Melatonin treated Hypothyroid. Values expressed as mean ± SEM of six animals; aP < 0.01; bP < 0.005; cP < 0.0005. | ||||||
C | 2.51 ± 0.51 | 3.03 ± 0.71 | 6.53 ± 0.65 | 38.0 ± 1.3 | 117.0 ± 6.1 | 236.8 ± 25.5 |
HPOT + MT | 1.39 ± 0.43 | 5.50 ± 0.86 | 7.98 ± 0.37 | 28.2 ± 3.7c | 268.2 ± 8.6c | 324.4 ± 18.5c |