Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 9, Number 4, August 2019, pages 90-94
Dapagliflozin Add-On Therapy Improves Body Composition and Metabolic Parameters in Overweight Type 2 Diabetic Patients: A Pilot Study
Tables
Group A: metformin+ insulin (n = 25) | Group B: metformin (n = 31) | |
---|---|---|
The difference was not significant for each variable. ASA: acetylsalicylic acid; BMI: body mass index; WC: waist circumference; FPG: fasting plasma glucose; TC: total cholesterol; HDL: high-density lipoprotein; TG: triglycerides; Hct: hematocrit; eGFR: estimated glomerular filtration rate; AER: albumin excretion rate; BUN: blood urea nitrogen; AST: aspartate transaminase; ALT: alanine transaminase; FM: fat mass; FFM: fat free mass; TBW: total body water; ECW: extra-cellular water; pA: phase angle. | ||
Age (years) | 56 ± 10.8 | 60 ±11 |
Diabetes duration (years) | 16 ± 3 | 15 ± 2 |
Antiplatelets (ASA) | 22/25 | 26/31 |
Statins | 23/25 | 27/31 |
Antihypertensive drugs | 24/25 | 28/31 |
Weight (kg) | 90.7 ± 13.1 | 90.4 ± 12.4 |
BMI (kg/m2) | 34.4 ± 8.3 | 31.2 ± 4.5 |
WC (cm) | 111.1 ± 18.5 | 110.3 ± 13 |
FPG (mg/dL) | 179 ± 65 | 168 ± 35 |
HbA1c (mmol/mol) | 74 ± 11.8 (8.9±1.9%) | 66 ± 6.2 (8.2±1%) |
TC (mg/dL) | 174.4 ± 35.1 | 186.7 ± 56.4 |
HDL (mg/dL) | 48.3 ± 19.7 | 50.0 ± 18 |
TG (mg/dL) | 156.0 ± 123.2 | 182.7 ± 67.5 |
Creatinine (mg/dL) | 0.8 ± 0.2 | 0.9 ± 0.2 |
Hct (%) | 41 ± 3.0 | 40 ± 3.4 |
eGFR (mL/min/1.73 m2) | 82.4 ± 23.4 | 83.7 ± 20.3 |
AER (µg/min) | 56 ± 12.2 | 49.0 ± 11.9 |
BUN (mg/dL) | 31.2 ± 7.1 | 33.5 ± 12.9 |
AST (U/L) | 23.9 ± 6.1 | 21.5 ± 3.8 |
ALT (U/L) | 25 ± 8.8 | 24.2 ± 5.9 |
FM (kg) | 30.5 ± 7.9 | 30.0 ± 6.2 |
FFM (kg) | 60.2 ± 5.2 | 60.4 ± 6.2 |
TBW (L) | 42.2 ± 7 | 43.1 ± 4.4 |
ECW (L) | 39.1 ± 4 | 39.2 ± 4.1 |
pA (°) | 5.3 ± 0.8 | 5.2 ± 0.7 |
Group A: metformin + insulin (n = 25) | Group B: metformin (n = 31) | |||||
---|---|---|---|---|---|---|
T0 | T1 | P-value | T0 | T1 | P-value | |
BMI: body mass index; WC: waist circumference; FPG: fasting plasma glucose; TC: total cholesterol; HDL: high-density lipoprotein; TG: triglycerides; Hct: hematocrit; eGFR: estimated glomerular filtration rate; AER: albumin excretion rate; BUN: blood urea nitrogen; AST: aspartate transaminase; ALT: alanine transaminase; BIA: bioelectrical impedance analysis; FM: fat mass; FFM: fat free mass; TBW: total body water; ECW: extra-cellular water; pA: phase angle. | ||||||
Age (years) | 56 ± 10.8 | 60 ± 11 | ||||
Weight (kg) | 90.7 ± 13.1 | 88.2 ± 16.3 | < 0.0001 | 90.4 ± 12.4 | 87.0 ± 13.6 | < 0.0001 |
BMI (kg/m2) | 34.4 ± 8.3 | 33.4 ± 8.2 | < 0.0001 | 31.2 ± 4.5 | 30 ± 3.4 | < 0.0001 |
WC (cm) | 111.1 ± 18.5 | 108.9 ± 18.7 | < 0.0001 | 110.3 ± 13 | 107.5 ± 12.9 | < 0.0001 |
FPG (mg/dL) | 179 ± 65 | 136 ± 49 | 0.007 | 168 ± 35 | 139 ± 24 | < 0.0001 |
HbA1c (mmol/mol) | 74 ± 11.8 (8.9±1.9%) | 64 ± 10.5 (8.0±1.7%) | < 0.0001 | 66 ± 6.2 (8.2±1%) | 56 ± 5.58 (7.3±0.9%) | < 0.0001 |
TC (mg/dL) | 174.4 ± 35.1 | 161 ± 31.7 | ns | 186.7 ± 56.4 | 177 ± 45.3 | ns |
HDL (mg/dL) | 48.3 ± 19.7 | 49.2 ± 18.1 | ns | 50.0 ± 18 | 51.5 ± 18.6 | ns |
TG (mg/dL) | 156.0 ± 123.2 | 133.3 ± 123.8 | 0.002 | 182.7 ± 67.5 | 149.8 ± 54.9 | 0.002 |
Hct (%) | 41 ± 3.0 | 41 ± 2.9 | ns | 40 ± 3.4 | 41 ± 3.0 | ns |
Creatinine (mg/dL) | 0.8 ± 0.2 | 0.8 ± 0.1 | ns | 0.9 ± 0.2 | 0.8 ± 0.2 | ns |
eGFR (mL/min/1.73 m2) | 82.4 ± 23.4 | 87.8 ± 16.9 | ns | 83.7 ± 20.3 | 88.5 ± 22.1 | ns |
AER (µg/min) | 56 ± 12.2 | 42 ± 11 | ns | 49.0 ± 11.9 | 36 ± 11.2 | ns |
BUN (mg/dL) | 31.2 ± 7.1 | 32.1 ± 9.8 | ns | 33.5 ± 12.9 | 33 ± 12.8 | ns |
AST (U/L) | 23.9 ± 6.1 | 24.1 ± 6.8 | ns | 21.5 ± 3.8 | 21.9 ± 3.6 | ns |
ALT (U/L) | 25 ± 8.8 | 23.2 ± 9.3 | ns | 24.2 ± 5.9 | 22.1 ± 6 | ns |
BIA | ||||||
FM (kg) | 30.5 ± 7.9 | 28.2 ± 8.2 | < 0.001 | 30.0 ± 6.2 | 26.4 ± 7.0 | < 0.001 |
FFM (kg) | 60.2 ± 5.2 | 59.5 ± 8.1 | ns | 60.4 ± 6.2 | 59.3 ± 6.6 | ns |
TBW (L) | 42.2 ± 7 | 40.6 ± 7.9 | ns | 43.1 ± 4.4 | 40.9 ± 4.9 | ns |
ECW (L) | 39.1 ± 4 | 37.3 ± 3 | ns | 39.2 ± 4.1 | 35.7 ± 4.2 | 0.021 |
pA (°) | 5.3 ± 0.8 | 5.5 ± 0.5 | ns | 5.2 ± 0.7 | 5.6 ± 0.6 | ns |