Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 9, Number 3, June 2019, pages 37-42
Differences in Clinical and Laboratory Findings Among Graves’ Disease, Painless Thyroiditis and Subacute Thyroiditis Patients With Hyperthyroidism
Tables
Graves’ disease | Painless thyroiditis | Subacute thyroiditis | ||||
---|---|---|---|---|---|---|
n | Values | n | Values | n | Values | |
Values except for sex indicate mean ± SD. *P < 0.001 versus patients with Graves’ disease and painless thyroiditis. | ||||||
Age (years) | 69 | 49.0 ± 18.0 | 7 | 46.9 ± 21.5 | 10 | 53.6 ± 17.3 |
Sex (female, n (%)) | 69 | 55 (79.7%) | 7 | 5 (71.4%)* | 10 | 3 (30%)* |
Body temperature (°C) | 35 | 36.7 ± 0.4 | 7 | 37.0 ± 0.5 | 8 | 37.1 ± 0.8 |
Pulse rate (beats/min) | 49 | 102.7 ± 17.6 | 6 | 91.5 ± 15.1 | 9 | 96.0 ± 21.6 |
Graves’ disease | Painless thyroiditis | Subacute thyroiditis | ||||
---|---|---|---|---|---|---|
n | Values | n | Values | n | Values | |
Values indicate mean ± SD. Tg-Ab: thyroglobulin antibody; TPO-Ab: thyroid peroxidase antibody; TRAb: TSH receptor antibody; TSH: thyroid-stimulating hormone; T3: triiodothyronine; T4: thyroxine. *P ≤ 0.001 versus patients with Graves’ disease. | ||||||
TSH (µSH/mL) | 69 | 0.03 ± 0.01 | 7 | 0.06 ± 0.09 | 10 | 0.03 ± 0.03 |
Free T3 (pg/mL) | 61 | 14.0 ± 8.0 | 6 | 4.5 ± 1.3* | 9 | 8.6 ± 3.3* |
Free T4 (µr/dL) | 69 | 3.7 ± 1.9 | 7 | 1.7 ± 0.4* | 10 | 2.9 ± 0.9 |
Free T3/Free T4 | 61 | 3.6 ± 0.7 | 6 | 2.7 ± 0.4* | 9 | 3.1 ± 0.8 |
Third-generation TRAb (IU/L) | 37 | 16.2 ± 11.9 | 5 | 0.2 ± 0.3* | 5 | 0.6 ± 0.2* |
TPO-Ab (IU/mL) | 53 | 151.6 ± 199.2 | 7 | 8.3 ± 3.2* | 9 | 9.7 ± 4.5* |
Tg-Ab (IU/mL) | 51 | 207.4 ± 257.3 | 7 | 316.3 ± 196.9 | 9 | 14.1 ± 3.4* |
Graves’ disease | Painless thyroiditis | Subacute thyroiditis | ||||
---|---|---|---|---|---|---|
n | Values | n | Values | n | Values | |
Values indicate mean ± SD. *P < 0.05 versus patients with Graves’ disease. | ||||||
White blood cells (/µL) | 66 | 5,527.3 ± 1,780.4 | 7 | 6,385.7 ± 3,913.0 | 10 | 9,780.0 ± 4,013.3* |
Neutrophils (%) | 56 | 52.6 ± 12.6 | 6 | 64.4 ± 14.6 | 7 | 69.3 ± 11.7* |
Lymphocytes (%) | 56 | 36.7 ± 10.8 | 6 | 27.2 ± 13.3 | 7 | 22.8 ± 11.7* |
Monocytes (%) | 56 | 7.7 ± 2.5 | 6 | 6.3 ± 2.2 | 7 | 6.6 ± 2.1 |
Eosinophils (%) | 56 | 2.9 ± 2.6 | 6 | 1.7 ± 1.5 | 7 | 1.2 ± 1.2* |
Graves’ disease | Painless thyroiditis | Subacute thyroiditis | ||||
---|---|---|---|---|---|---|
n | Values | n | Values | n | Values | |
Values indicate mean ± SD. *P < 0.05 versus patients with Graves’ disease. | ||||||
Albumin (g/dL) | 61 | 4.1 ± 0.5 | 6 | 4.2 ± 0.4 | 9 | 3.7 ± 0.4* |
Aspartate transaminase (U/L) | 69 | 27.3 ± 16.5 | 7 | 23.9 ± 7.4 | 10 | 25.9 ± 9.1 |
Alanine aminotransferase (U/L) | 69 | 34.6 ± 28.0 | 7 | 23.0 ± 7.4* | 10 | 40.0 ± 19.0 |
Alkaline phosphatase (U/L) | 57 | 367.2 ± 154.6 | 4 | 225.0 ± 56.8* | 7 | 320.7 ± 108.2 |
Gamma-glutamyl transpeptidase (U/L) | 57 | 36.8 ± 34.5 | 3 | 30.0 ± 5.3 | 8 | 72.6 ± 75.8 |
Creatine kinase (U/L) | 55 | 66.4 ± 50.2 | 5 | 74.0 ± 26.2 | 9 | 73.8 ± 44.9 |
Total bilirubin (mg/dL) | 52 | 0.7 ± 0.5 | 5 | 0.6 ± 0.2 | 3 | 0.6 ± 0.1 |
Triglyceride (mg/dL) | 49 | 105.0 ± 57.0 | 4 | 105.8 ± 39.9 | 7 | 129.4 ± 79.5 |
High-density lipoprotein cholesterol (mg/dL) | 43 | 52.9 ± 10.8 | 4 | 52.8 ± 8.5 | 7 | 43.3 ± 13.6 |
Low-density lipoprotein cholesterol (mg/dL) | 47 | 83.3 ± 27.7 | 4 | 88.3 ± 17.0 | 7 | 81.6 ± 24.4 |
Blood urea nitrogen (mg/dL) | 69 | 14.9 ± 5.0 | 7 | 12.4 ± 6.1 | 9 | 16.1 ± 13.6 |
Creatinine (mg/dL) | 69 | 0.5 ± 0.2 | 7 | 0.6 ± 0.2* | 10 | 0.7 ± 0.3 |
Uric acid (mg/dL) | 53 | 5.3 ± 1.5 | 3 | 5.7 ± 1.1 | 8 | 5.5 ± 1.8 |
Plasma glucose (mg/dL) | 58 | 114.7 ± 26.9 | 5 | 115.0 ± 27.5 | 6 | 127.8 ± 21.3 |
B-type natriuretic peptide (pg/mL) | 28 | 87.4 ± 109.8 | 4 | 61.6 ± 91.1 | 2 | 26.1 ± 27.8 |
C-reactive protein (mg/dL) | 52 | 0.2 ± 0.4 | 6 | 2.4 ± 4.8 | 10 | 4.8 ± 4.0* |