Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website https://www.jofem.org

Original Article

Volume 10, Number 6, December 2020, pages 173-181


Epicardial Adipose Tissue Thickness as a Reliable Marker of Increased Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus

Figures

Figure 1.
Figure 1. NCCT of chest showing EAT thickness in a case subject. NCCT: non-contrast computed tomography; EAT: epicardial adipose tissue.
Figure 2.
Figure 2. NCCT of chest showing EAT thickness in a control. NCCT: non-contrast computed tomography; EAT: epicardial adipose tissue.
Figure 3.
Figure 3. Comparison of EAT thickness between cases and controls. EAT: epicardial adipose tissue.
Figure 4.
Figure 4. Comparison of CIMT between cases and controls. CIMT: carotid intima-media thickness.
Figure 5.
Figure 5. Receiver operating characteristics curve of the EAT thickness to differentiate between diabetic and control group. EAT: epicardial adipose tissue.

Tables

Table 1. Baseline Characteristics of the Study Population (n = 50)
 
CasesControlsP value
SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; TLC: total leukocyte count; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; FBS: fasting blood sugar; PPBS: post prandial blood sugar; AST: aspartate transaminase; ALT: alanine transaminase; ALP: alkaline phosphatase; EAT: epicardial adipose tissue; CIMT: carotid intima-media thickness.
Age (in years)47.48 ± 7.3739.70 ± 4.24-
Male (%)37.580.0-
Female (%)62.520.0-
Duration(years)5.83 ± 4.02--
Pulse rate (beats per minute)76.35 ± 5.5476.01 ± 3.330.95
SBP (mm Hg)126.05 ± 5.51119.01 ± 6.48< 0.01
DBP (mm Hg)77.15 ± 4.3978.40 ± 3.240.64
BMI (kg/m2)19.92 ± 1.4820.82 ± 0.930.04
Hb (g/dL)12.71 ± 1.3714.06 ± 0.55< 0.01
TLC (/µL)7,181.50 ± 1,787.466,570.01 ± 1,629.620.43
P/C (in Lakhs)2.13 ± 0.552.39 ± 0.550.12
Blood urea (mg/dL)27.99 ± 10.4526.50 ± 3.590.85
Serum creatinine (mg/dL)0.825 ± 0.1410.79 ± 0.120.43
TG (mg/dL)101.33 ± 23.5793.80 ± 20.920.52
Total cholesterol (mg/dL)153.55 ± 24.60115.90 ± 30.89< 0.01
LDL (mg/dL)96.90 ± 17.1677.30 ± 9.94< 0.001
HDL (mg/dL)40.65 ± 4.2243.20 ± 5.110.13
FBS (mg/dL)162.03 ± 55.2495.00 ± 4.9< 0.001
PPBS (mg/dL)234.70 ± 74.72112.60 ± 7.19< 0.001
HbA1c (%)9.27 ± 2.554.98 ± 0.22< 0.001
Calcium (mg/dL)8.95 ± 0.349.10 ± 0.210.11
Phosphate (mg/dL)3.77 ± 0.353.97 ± 0.270.10
Total bilirubin (mg/dL)0.76 ± 0.130.79 ± 0.090.51
Direct bilirubin (mg/dL)0.26 ± 0.090.21 ± 0.050.18
AST (IU/L)30.38 ± 10.8327.20 ± 4.160.29
ALT (IU/L)34.03 ± 15.4925.50 ± 3.410.11
ALP58.70 ± 6.6449.30 ± 14.600.05
Total protein (mg/dL)7.32 ± 0.367.59 ± 0.330.03
Serum albumin (mg/dL)3.95 ± 0.204.04 ± 0.160.23
EAT thickness (mm)8.70 ± 2.943.48 ± 0.99< 0.001
CIMT (mm)0.65 ± 0.260.56 ± 0.120.17

 

Table 2. Correlations of the Epicardial Adipose Tissue Thickness With Different Variables in Diabetic Patients
 
r valueP value
BMI: body mass index; CIMT: carotid intima-media thickness; FBS: fasting blood sugar; PPBS: post prandial blood sugar; TG: triglyceride.
HbA1c0.86< 0.001
Duration of diabetes0.340.02
Age0.180.26
BMI0.81< 0.001
CIMT0.210.17
FBS-0.230.13
PPBS-0.220.17
TG0.93< 0.001
Total cholesterol0.94< 0.001