Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website https://www.jofem.org

Short Communication

Volume 11, Number 1, February 2021, pages 28-32


The Role of Inflammation in Contributing to Vascular Risk in Subclinical Hyperthyroidism: Randomized Controlled Trial

Figure

Figure 1.
Figure 1. SH study flow chart. SH: subclinical hyperthyroidism; BP: blood pressure; CRP: C-reactive protein; Lp-PLA2: lipoprotein associated phospholipase A2; NLR: neutrophil to lymphocyte ratio; MLR: monocyte to lymphocyte ratio; TSH: thyroid stimulating hormone; FT4: free thyroxine; PLB: placebo.

Table

Table 1. Comparisons Between SH Patients on Carbimazole and Placebo at Baseline and at 6 Months
 
CharacteristicsPlacebo (n = 18)Carbimazole (n = 12)P1P2
All data except age and sex are expressed as median and range. P1 and P2 are the differences between placebo and carbimazole groups at visit 0 and visit 2, respectively. IHD: ischemic heart disease; BMI: body mass index; BP: blood pressure; TSH: thyroid stimulating hormone; FT4: free thyroxine; CRP: C-reactive protein; Lp-PLA2: lipoprotein associated phospholipase A2; NLR: neutrophil to lymphocyte ratio; MLR: monocyte to lymphocyte ratio.
Age (years)57 (46 - 63)55 (44 - 65.5)0.96-
Sex M/F (%)5/13 (27.8/72.2)3/9 (25/75)0.99-
Diabetes (%)6 (33.3)4 (33.3)0.99-
Hypertension (%)8 (44.4)5 (41.7)0.99-
Hyperlipidemia (%)6 (33.3)4 (33.3)0.99-
IHD (%)1 (5.6)1 (8.3)0.99-
Atrial fibrillation00--
BMI (kg/m2)0.270.22
  Visit 023.4 (21.1 - 26.3)25.0 (24.2 - 26.5)
  Visit 223.6 (21.6 - 26.6)25.2 (24.3 - 26.8)
Systolic BP0.790.30
  Visit 0127.5 (119 - 140)128.5 (109.5 - 138.5)
  Visit 2130.0 (116 - 146)124.5 (109.0 - 144.0)
Diastolic BP0.640.34
  Visit 071 (68 - 74)65.5 (63.5 - 82)
  Visit 270.5 (68 - 76)76.0 (68.5 - 82.0)
FT4 (pmol/L)0.450.06
  Visit 013 (12 - 15)13 (11.5 - 13.5)
  Visit 212.5 (11 - 14)11.5 (10.5 - 12.0)
TSH (mIU/L)0.680.0008
  Visit 00.19 (0.14 - 0.27)0.25 (0.1 - 0.29)
  Visit 20.33 (0.20 - 0.48)1.1 (0.7 - 2.3)
CRP (mg/L)0.980.52
  Visit 01.1 (0.20 - 16.8)1.5 (0.20 - 6.2)
  Visit 21.05 (0.2 - 11.3)1.1 ( 0.2 - 7.0)
Lp-PLA2 (ng/mL)0.080.15
  Visit 0443.33 (55.98 - 7,129.43)191.16 (52.44 - 1,244.75)
  Visit 2455.21 (68.87 - 3,904.35)207.79 (58.18 - 827.35)
NLR0.280.87
  Visit 01.69 (0.96 - 3.49)1.79 (1.10 - 5.21)
  Visit 22.10 (1.49 - 2.43)2.06 (1.59 - 2.52)
MLR0.340.29
  Visit 00.23 (0.12 - 0.41)0.26 (0.15 - 0.39)
  Visit 20.23 (0.20 - 0.28)0.23 (0.21 - 0.31)