Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website https://www.jofem.org |
Original Article
Volume 11, Number 3-4, August 2021, pages 76-82
Late Impact of COVID-19 Pneumonia on Testosterone Levels in Recovered, Post-Hospitalized Male Patients
Tables
COVID-19 pneumonia patients (n = 55) | Matched control (n = 40) | P value | |
---|---|---|---|
COVID-19: coronavirus disease 2019; ICU: intensive care unit; BMI: body mass index; WC: waist circumference; CCI: Charlson Comorbidity Index; CRP: C-reactive protein; TT: total testosterone; cFT: calculated free testosterone; LH: luteinizing hormone; SHBG: sex hormone binding globulin; T/LH: testosterone to LH ratio. | |||
Age (years) | 53.02 ± 7.385 | 51.80 ± 7.498 | 0.432 |
Smoker ratio | 21 (38.2%) | 16 (40%) | 0.858 |
ICU admission | 15 (29.3%) | ||
Hypertension | 29 (52.7%) | 19 (47.5%) | 0.615 |
Body weight (kg) | 105.93 ± 15.677 | 102.73 ± 16.123 | 0.334 |
Height (m) | 1.7416 ± 0.05862 | 1.7358 ± 0.06842 | 0.654 |
BMI (kg/m2) | 35.0776 ± 5.87218 | 34.2703 ± 6.06213 | 0.516 |
WC (cm) | 120.20 ± 16.875 | 115.55 ± 17.255 | 0.192 |
CRP (mg/L) | 15.8782 ±7.82614 | 14.175 ± 7.00417 | 0.277 |
CCI | 3 (3) | 3 (2) | 0.128 |
Albumin (g/dL) | 4.23 ± 0.19108 | 4.1564 ± 0.27200 | 0.145 |
SHBG (nmol/L) | 49.0091 ± 9.81952 | 49.8350 ± 9.21400 | 0.679 |
TT (ng/dL) | 335.8182 ± 148.116 | 401.35 ± 145.734 | 0.35 |
cFT (ng/dL) | 5.342909 ± 2.40896 | 6.3615 ± 2.314652 | 0.41 |
LH (mIU/L) | 7.6836 ± 2.69298 | 7.03 ± 2.47596 | 0.23 |
T/LH | 0.4731 (0.51) | 0.6584 (0.43) | 0.022 |
Testosterone deficiency prevalence | 28 (50.9%) | 12 (30%) | 0.042 |
Non-deficient testosterone (n = 27) | Deficient testosterone (n = 28) | P value | |
---|---|---|---|
COVID-19: coronavirus disease 2019; ICU: intensive care unit; BMI: body mass index; WC: waist circumference; CCI: Charlson Comorbidity Index; CRP: C-reactive protein; LH: luteinizing hormone; cFT: calculated free testosterone; SHBG: sex hormone binding globulin; T/LH: testosterone to LH ratio. | |||
Age (years) | 53.89 ± 7.617 | 52.18 ± 7.191 | 0.396 |
Smoker ratio | 10 (37%) | 11 (39.3%) | 0.864 |
Hospitalization time (days) | 5.19 ± 1.733 | 7.46 ± 3.226 | 0.002 |
ICU admission | 3 (11.1%) | 8 (28.6%) | 0.106 |
Hypertension | 12 (44.4%) | 17 (60.7%) | 0.227 |
Body weight (kg) | 102.00 ± 16.502 | 109.71 ± 14.108 | 0.068 |
Height (m) | 1.7496 ± 0.05977 | 1.7339 ± 0.05750 | 0.325 |
BMI (kg/m2) | 33.4579 ± 5.87564 | 36.6395 ± 5.52875 | 0.043 |
WC (cm) | 112.93 ± 16.146 | 127.21 ± 14.647 | 0.001 |
CRP (mg/L) | 14.1 ± 7.90569 | 17.5929 ± 7.49004 | 0.098 |
CCI | 3 (2) | 5 (4) | 0.007 |
Albumin (g/dL) | 4.2000 ± 0.26890 | 4.1143 ± 0.27314 | 0.246 |
SHBG (nmol/L) | 51.2222 ± 9.86257 | 46.8750 ± 9.46348 | 0.101 |
cFT (ng/dL) | 7.302593 ± 1.624783 | 3.453214 ± 1.2331 | 0.0001 |
LH (mIU/L) | 6.6889 ± 1.47187 | 8.6429 ± 3.23642 | 0.006 |
T/LH | 0.2449 (0.17) | 0.7058 (0.29) | 0.001 |
Model 1 | Model 2 | |||||
---|---|---|---|---|---|---|
B | β | P value | B | β | P value | |
Model 1 was unadjusted. Model 2 adjusted for age. COVID-19: coronavirus disease 2019; WC: waist circumference; BMI: body mass index; LH: luteinizing hormone; Sqrt CCI: square root of Charlson Comorbidity Index. | ||||||
WC | -5.895 | -2.932 | 0.005 | -5.941 | -2.991 | 0.004 |
BMI | 7.217 | 1.238 | 0.221 | 7.709 | 1.337 | 0.188 |
LH | -3.154 | -0.470 | 0.641 | -1.600 | -0.238 | 0.813 |
Hospitalization time | -9.768 | -1.599 | 0.116 | -9.866 | -1.635 | 0.109 |
Sqrt CCI | -67.069 | -1.976 | 0.054 | -78.849 | -2.288 | 0.027 |