Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website https://www.jofem.org

Original Article

Volume 13, Number 1, February 2023, pages 33-38

The Severity of Bone Loss: A Comparison Between Cushing’s Disease and Cushing’s Syndrome

Tables

Table 1. Comparison Between ACS and CD Regarding Demographics and Clinical Characteristics, Hormonal Profile, and Other Biochemical Markers of Bone Metabolism
 
ACS (n = 8)CD (n = 19)P value
Data are presented as mean ± standard error. *P ≤ 0.05. ACS: adrenal-dependent Cushing’s syndrome; CD: Cushing’s disease; BMI: body mass index; ACTH: adrenocorticotropic hormone; DHEA-S: dehydroepiandrosterone sulfate; UFC: urinary free cortisol; 25(OH)D3: 25-hydroxyvitamin D3; PTH: parathyroid hormone: Ca: calcium; P: phosphorus.
Age (years)46.5 ± 3.0744.3 ± 0.340.48
Sex (male/female)3/55/140.16
BMI (kg/m2)26.32 ± 1.528.41 ± 0.490.535
ACTH (pg/mL)7.43 ± 1.4593.87 ± 4.62< 0.01*
DHEA-S (µg/L)86.0 ± 22.96302.9 ± 12.55< 0.01*
UFC (µg/24 h)647.5 ± 71.36405.6 ± 31.540.01*
Serum cortisol (mmol/L)549.5 ± 28.0574.8 ± 15.250.12
25(OH)D3 (nmol/L)39.15 ± 6.7638.02 ± 4.430.578
PTH (ng/L)49.60 ± 4.9826.10 ± 4.896< 0.01*
Serum Ca (mmol/L)2.08 ± 0.251.97 ± 0.030.053
Serum P (mmol/L)1.55 ± 0.251.67 ± 0.770.06

 

Table 2. Comparison Between ACS and CD Regarding the Prevalence of Osteoporosis
 
T-score valuesACS (n = 8)CD (n = 19)P value
*P ≤ 0.05. ACS: adrenal-dependent Cushing’s syndrome; CD: Cushing’s disease.
Normal1 (12.5%)4 (21.0%)< 0.01*
Osteopenia2 (25%)10 (52.6%)< 0.001*
Osteoporosis5 (62.5%)5 (26.3%)0.03*

 

Table 3. Comparison Between ACS and CD Regarding Bone Densitometric Values
 
ACSCDP value
Data are presented as mean ± standard deviation. *P ≤ 0.05. ACS: adrenal-dependent Cushing’s syndrome; CD: Cushing’s disease; BMD: bone mineral density.
BMD (g/cm2)0.83 ± 0.120.97 ± 0.320.011*
T-score-2.98 ± 0.16-1.91± 0.33< 0·01*