The Effect of Growth Hormone Treatment on Adult Height of Children With Idiopathic Short Stature: A Systematic Review and Meta-Analyses

Shoboo Rahmati, Nasrin Pourattar, Milad Azami, Ali Depisheh, Reza Najafi, Kourosh Sayehmiri

Abstract


Idiopathic short stature (ISS) is a kind of low height among children in which children’s height is more than 2 standard deviation (SD) scores below the mean score of the height of other children with the same age and gender. It is one of the disorders that physicians use growth hormone for its treatment. Therefore, the purpose of the current study was to investigate the effect of growth hormone treatment on the adulthood height of children with ISS through meta-analysis method. In total 20 studies with a sample size of 1,517 were included in the meta-analysis through searching in external databases, including Web of science, Pubmed, Cochran, Medline, Embase, Springer, Scopus, and Science Direct using mesh keywords as growth hormone, final height, adult height, and idiopathic short stature. Mean score and SD were utilized for measuring any increase in height growth and random effect model was used for combining studies. Further, I2 index was used for determining the heterogeneity of studies. Results indicated that before treatment, according to standard mean difference percentile of children’s height was -1.64 (95% confidence interval (CI): -2.01 to -1.28) which is equal to 5%. After treatment, according to standard mean difference percentile of children’s height came out to be 0.11 (95% CI: 0.07 - 0.14) which is equal to 54.38%. This indicates that percentile of children’s height has increased as a result of treatment with growth hormone. Through combining the results of all studies, the mean score for participants’ height before treatment was 5% and after treatment it reached 54%. Therefore, obtained mean difference for adult height after treatment with growth hormone was reported to be more than 1.4 SD score (about 7.6 cm). Growth hormone can be influential in increasing the adult height of children with ISS.




J Endocrinol Metab. 2017;7(2):45-54
doi: https://doi.org/10.14740/jem411w

Keywords


Idiopathic short stature; Adult height; Final height; Growth hormon; Meta-analysis

Full Text: HTML PDF
 
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


 

     

Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board

Archives

Copyright

Company Profile

Editorial Office

Misconduct and Retraction

Permissions

Company Registration

Contact Us

Abstracting and Indexing

ICMJE

Ownership

Instructions to Authors

Access

Declaration of Helsinki

Contact Publisher

Submission Checklist

Reprints

Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy

Disclaimer

Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians

Careers

Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal

       
       

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

DECLARATION: THIS JOURNAL SITE OUTLOOK IS DESIGNED BY THE PUBLISHER AND COPYRIGHT PROTECTED. DO NOT COPY!