Late-Onset Chronic Severe Painless Diarrhea Secondary to Metformin: Case Report and Literature Review

Jennifer L. M. Lowry, Tom T. T. Liu, Selina L. Liu


We present a case of late-onset chronic severe painless diarrhea in an 80-year-old man with type 2 diabetes who was on metformin for 5 years. He underwent multiple laboratory and imaging investigations with no underlying cause found. After detailed medication review, a trial of metformin discontinuation resulted in immediate resolution of symptoms. This case highlights the importance of considering metformin as a cause of new-onset diarrhea in patients even if they had previously tolerated the drug well for years, as its discontinuation can potentially prevent patient inconvenience and discomfort associated with unnecessary investigations.

J Endocrinol Metab. 2016;6(1):21-22


Metformin; Diarrhea; Late-onset

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