Non-Anti-Neutrophil Anti-Cytoplasmic Antibodies Associated Methimazole-Induced Nephritis: Case and Review of Literature

Hengyi Guo, David Levitt, Kashif M. Munir, Cynthia B. Drachenberg, Rana Malek, Elizabeth M. Lamos


Current anti-thyroid therapy is rarely associated with adverse effects such as vasculitis or nephritis. Historically, vasculitis associated with anti-thyroid therapy is associated with anti-neutrophil anti-cytoplasmic antibodies (ANCA). Here, we report a rare case of ANCA-negative interstitial nephritis secondary to methimazole, resulting in end organ renal failure. A 27-year-old male with a history of Graves’ hyperthyroidism on methimazole anti-thyroid therapy presented to the hospital with shortness of breath and chest pain, complicated by a pericardial effusion and acute kidney injury (AKI) requiring emergent hemodialysis. The diagnosis of drug-induced ANCA-negative vasculitis was based on the temporal relationship between clinically evident vasculitis and treatment with methimazole, after excluding other causes of vasculitis. The lack of ANCA-associated positivity should not deter clinicians from considering stopping the offending agent and pursuing more definitive therapy (radioactive iodine or surgery as appropriate).

J Endocrinol Metab. 2018;8(2-3):47-51


Methimazole; Interstitial nephritis; Renal failure; ANCA-negative vasculitis

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