Serologic Screening of Celiac Disease in Patients With Type 1 Diabetes

Eman M. Albatayneh, Nedal A. Alnawaiseh, Sameeh A. Al-Sarayreh, Yousef M. Al-saraireh, Enas M. Al-Zayadneh, Mohammad A. Abu-lobbad

Abstract


Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disorder associated with increased risk of additional autoimmune diseases (ADs) as celiac disease (CD). The aim of this study was to investigate the prevalence of CDs in a population of diabetic children along with the presence of any suggestive clinical signs and symptoms of CD and any effects of CD on the patients’ diabetic control and growth.

Methods: Data from diabetic patients in South Jordan attending the diabetic clinic in the military hospital between 2014 and 2015 were collected. The frequency of CD was calculated. A t-test comparison between CD-seropositive and seronegative diabetic patients, the unadjusted and adjusted odds ratios (ORs) for age, gender, baseline glycated hemoglobin (HbA1c), cholesterol and glucose levels, associated diseases, and body mass index with their 95% confidence intervals (CIs) were evaluated.

Results: One hundred thirty-eight patients with T1DM (median age 16.5 years; 74 females) were recruited. The results showed that CD was in (6.5%) of the patients. The body weight, body mass index, baseline HbA1c and cholesterol levels were significantly different between seropositive and seronegative patients (P < 0.05). Adjusted ORs for the presence eczema and family history of T1DM in seropositive CD were 32.66 (95% CI: 2.68 - 398.85, P = 0?.0006), and 5.79 (95% CI: 1.07 - 31.33, P= 0.041), respectively. While the adjusted odd ratio of having high HbA1c and high cholesterol levels in seropositive were 1.76 (95% CI: 1.13 - 2.74, P = 0.01) and 1.02 (95% CI: 1.006 - 1.031, P < 0.001) respectively.

Conclusions: These findings suggest a need for a careful surveillance of CD in patients with T1DM. This may help in improving the diabetic control and growth control, and avoidance of complications.




J Endocrinol Metab. 2018;8(2-3):37-42
doi: https://doi.org/10.14740/jem507w

Correction in J Endocrinol Metab. 2020;10(1):32, doi: 10.14740/jem507wc1


Keywords


Type 1 diabetes mellitus; Celiac disease; Autoimmune disease; Diabetic control

Full Text: HTML PDF
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.