Adipose Tissue Hypoxia, A Conceptual Alometric View

Marià Alemany

Abstract


Hypoxia is a condition in which there is an insufficiency of oxygen for normal cell operation. It is directly related to diminished oxygen supply, usually because of restricted/insufficient blood circulation or defective oxygen transport and release. However, in absolute terms, cells in a small size animal may experience hypoxia with an oxygen supply comparable to that of normalcy in larger animals. The question is, essentially, the alometrically-related metabolic rate which translates into the actual individual cell metabolism. Cells in large animals consume less oxygen in vivo than their smaller animal counterparts, but this is not translated into hypoxia in the former. The critical point is not the absolute oxygen supply but the relationship of this to the incorporation of substrates to oxidize. It is the alteration of the ratio between oxidizable substrates and oxygen availability, the factor eliciting the ravages of hypoxia. The normal function of the circulatory system maintains a balanced supply of both terms of the equation; however, substrate oversupply, such as that experienced by adipose tissue in the metabolic syndrome may break the equilibrium, eliciting hypoxia and acidosis, which may derive into inflammation and further cell and tissue damage. 




J Endocrinol Metab. 2011;1(4):155-158
doi: https://doi.org/10.14740/jem52w


Keywords


Hypoxia; Acidosis; Adipose tissue; Inflammation; Metabolic syndrome

Full Text: HTML PDF
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.