Irisin: As a Therapeutic Target for Metabolic Disorders

Ikram Ullah Khan


During physical activity, muscle expresses a panel of proteins named as myokines which exert beneficial effects on the distant organs of the body. Irisin is a relatively newly discovered myokine mainly secreted by the skeletal muscles. This myokine is a cleavage fragment of a transmembrane protein known as fibronectin domain-containing protein 5 (FNDC5). Irisin is known to have multi-spectrum functions including browning of adipose tissue (BAT), enhancing insulin sensitivity, cognition, osteogenesis and metabolism. Due to these functions, irisin has a wide range of therapeutic effects on obesity, diabetes mellitus, hypertension, cardiovascular diseases, chronic kidney diseases, cancer and dementia. In current, our focus is emphasized upon the therapeutic aspects of irisin and its possible role in the diagnoses of various metabolic disorders.

J Endocrinol Metab. 2018;8(5):87-93


Irisin; FNDC5; Myokine; Obesity; Diabetes; PCOS

Full Text: HTML PDF
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe



Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board



Company Profile

Editorial Office

Misconduct and Retraction


Company Registration

Contact Us

Abstracting and Indexing



Instructions to Authors


Declaration of Helsinki

Contact Publisher

Submission Checklist


Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy


Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians


Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal


Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.