Two Cases of Rapidly Growing Papillary Thyroid Carcinoma After Radioactive Iodine Therapy for Graves’ Disease

Seigo Tachibana, Tadao Yokoi, Shinya Sato, Nobuhiro Nakatake, Shuji Fukata, Junichi Tajiri, Hiroyuki Yamashita

Abstract


We herein report two cases of papillary thyroid carcinoma (PTC) after radioactive iodine therapy (RIT) for Graves’ disease (GD). Case 1: A 25-year-old man visited to our clinic. He had undergone RIT for GD at 23 years old. His thyroid function was severe hypothyroidism because of poor compliance of taking levothyroxine (LT4), and thyroid nodule was detected by neck ultrasonography (US). After his first visit, his compliance of taking LT4 maintained poor, then his thyroid nodule grew up from 7 mm to 12 mm for 9 months. Fine needle aspiration biopsy (FNAB) was performed and the result of FNAB suggested PTC. Therefore, total thyroidectomy was done. Case 2: A 40-year-old woman was referred to our clinic for the treatment of PTC. She had also undergone RIT for GD at 34 years old. When she was 39 years old, a thyroid nodule was detected by neck US. Her compliance of taking LT4 was also poor, and the nodule grew up from 11 mm to 19 mm for 12 months. The result of FNAB was suggestive of PTC. Therefore, total thyroidectomy was done. In both two cases, thyroid nodular lesion could not be detected by neck US before RIT. In conclusion, we considered that this rapid growth of PTC in the irradiated thyroid gland may be induced by TSH stimulation, and that routine neck US should be continued after RIT for GD, even if there is no tumor in the thyroid before RIT.




J Endocrinol Metab. 2012;2(3):145-150
doi: https://doi.org/10.4021/jem84w

Keywords


Radioactive iodine therapy; Papillary thyroid carcinoma; Graves’ disease; Hypothyroidism

Full Text: HTML PDF
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.