Prevalence and Clinical Characteristics of Pretibial Myxedema in Chinese Outpatients With Thyroid Diseases

Changgui Lan, Wei Chen, Jing Zhao, Can Li, Xiaofeng Mei, Jie Hu

Abstract


Background: There have been no reports on the prevalence of pretibial myxedema (PTM) in thyroid diseases in China. In order to resolve the problem, we retrospectively investigated Chinese outpatients with thyroid diseases and analyzed the clinical manifestation of PTM.

Methods: All outpatients with thyroid diseases at Department of Nuclear Medicine from October 24, 2000 to November 11, 2006 were included in the investigation by eligible case criteria and screened by PTM diagnosis criteria. The fill-out forms of PTM had three main items which contained demographics, diagnosis of thyroid diseases, relationship among I-131 therapy, thyroid function and onset of PTM, and the clinical manifestation of PTM. Descriptive statistics of the data were performed with statistical software SPSS17.0.

Results: The prevalence of PTM was 1.6% (728/44,646) in thyroid diseases, 1.7% in thyrotoxicosis, and 0.36% in Hashimoto thyroiditis, primary hypothyroidism and thyroid adenoma, respectively. The average age was 41.1 ± 11.9 years (15 - 78 years). The sex ratio was 1:3.7. Eighty-three percent of cases were Chinese farmers. The onset of PTM was 63.9% in euthyroidism, 22% in hyperthyroidism, 11.4% in hypothyroidism and 2.7% in unclear thyroid function. The course was 10 days to 10 years and its average was 37.8 ± 20.5 months. The clinical forms were 82.6% in non-pitting diffuse swelling, 12.4% in plaque/nodule, 2.7% in verruciform plaque, 1.6% in elephantiasis and 0.7% in tumorous.

Conclusions: The prevalence of PTM with chronic and autoimmune features is 1.6% in thyroid diseases. Its onset is not related to thyroid dysfunction and it should be treated early.




J Endocrinol Metab. 2015;5(4):250-255
doi: http://dx.doi.org/10.14740/jem306e



Keywords


Pretibial myxedema; Prevalence; Thyroid disease; Thyroid dysfunction; Clinical manifestation; I-131 treatment

Full Text: HTML PDF
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.